Clogged filter

The Protease Ste24 Clears Clogged Translocons

Translocation into the endoplasmic reticulum (ER) is the first step in the biogenesis of thousands of eukaryotic endomembrane proteins. Although functional ER translocation has been avidly studied, little is known about the quality control mechanisms that resolve faulty translocational states. One such faulty state is translocon clogging, in which the substrate fails to properly translocate and...

A clogged gutter mechanism for protease inhibitors.

A classical peptide inhibitor of serine proteases that is hydrolyzed approximately 10(7) times more slowly than a good substrate is shown to form an acyl-enzyme intermediate rapidly. Despite this quick first step, further reaction is slowed dramatically because of tight and oriented binding of the cleaved peptide, preventing acyl-enzyme hydrolysis and favoring the reverse reaction. Moreover, th...

Coronary artery disease as clogged pipes: a misconceptual model.

Plugging of porous media and filters: Maximum clogged porosity

We model porous media as two-dimensional networks of channels. As suspension flows through the network, particles clog channels. Assuming no flow through clogged channels, we determine an upper bound on the number of channels that clog and leave the network impervious. More precisely, the number of channels that clog does not exceed the number of faces of the multigraph associated with the netw...

A New Look at Cholesterol, Cancer, Clogged Arteries & EFAs

The clinical failure of Vytorin in the ENHANCE trial is further confirmation that the medical community needs to re-evaluate the efficacy of using statin drugs for the widespread treatment and prevention of CAD (coronary artery disease). Statins were marketed on the precept that lowering so-called “bad” cholesterol while raising “good” cholesterol significantly improves cardiovascular outcomes....